Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID 100ML
NC3241523 TRIFLUOROACETIC ACID 100ML
Medchemexpress LLC MM-401 TFA | 1442106-11-7 | 99.3% | 700.75 | 1 MG
MM-401 (TFA) is an MLL1 H3K4 methyltransferase inhibitor. It inhibits MLL1 activity with an IC50 of 0.32 μM by blocking the MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis, and differentiation and can be used for research into MLL leukemia.
- Target specificity: Inhibits MLL1 H3K4 methyltransferase activity by blocking MLL1-WDR5 interaction.
- Potency: Inhibits MLL1 activity with an IC50 of 0.32 μM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM.
- Cellular effects: Induces cell cycle arrest, apoptosis, and differentiation.
- Research application: Useful for research of MLL leukemia.
- Purity: 99.34%.
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 1 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound works by inhibiting p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- IC50 of 50-500 nM for p300
- Over 100-fold selectivity for p300 compared to PCAF
- Induces a senescent phenotype in human normal melanocytes at 0.1 and 1 mM concentrations
- Inhibits cyclin E expression in a dose-dependent manner
Medchemexpress LLC MM-401 (TFA) | 1442106-11-7 | 99.3% | 700.75 | 5 MG
MM-401 (TFA) is an inhibitor of MLL1 H3K4 methyltransferase. It works by blocking the interaction between MLL1 and WDR5, thereby inhibiting MLL1 activity with an IC50 of 0.32 μM. This compound can induce cell cycle arrest, apoptosis, and differentiation. It is used in research for MLL leukemia.
- Inhibits MLL1 H3K4 methyltransferase
- Blocks MLL1-WDR5 interaction
- Potent inhibition of MLL1 activity
- Induces cell cycle arrest
- Promotes apoptosis
- Facilitates differentiation
- Useful for research of MLL leukemia
- Specifically inhibits MLL1-dependent H3K4 methylation in cells
- Inhibits growth of MLL leukemia cells
- Affects MLL-AF9 transcriptome
Medchemexpress LLC UNC4976 trifluoroacetate | 98.0% | 961.12 g/mol | C49H71F3N6O10 | 5 MG
UNC4976 TFA is the trifluoroacetate salt of UNC4976, a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain that modulates chromodomain-nucleic acid interactions. It is supplied as a purified research compound intended for in vitro studies in epigenetics and chromatin biology.
- Trifluoroacetate salt form for improved handling and stability.
- High purity suitable for research applications (98.0%).
- Molecular formula C49H71F3N6O10 and molecular weight 961.12 g/mol.
- Available in small pack sizes for screening and assay development.
- Suitable for use in studies of chromodomain function and epigenetic modulation.
- Provided with documentation specifying identity and purity.
Medchemexpress LLC ALX-1393 TFA | 949164-09-4 | 99.8% | 509.45 | 50 MG
ALX-1393 TFA is a selective glycine transporter-2 (GlyT2) inhibitor that demonstrates an antinociceptive effect, meaning it helps reduce pain. This compound has been observed to alleviate pain responses to thermal, mechanical, and chemical stimulations in a rat acute pain model. In experimental settings, administration of the compound has been shown to suppress the late-phase response in the formalin test and inhibit mechanical and cold hyperalgesia in a dose-dependent manner, without affecting motor performance in normal rats.
- Selectively inhibits a specific neuronal transporter.
- Exhibits pain-reducing effects across various types of pain stimuli.
- Effective in inflammatory and neuropathic pain models.
- Does not impair motor function.
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 1mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology
![Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000397365.png-250.jpg)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue.
- Acts as a GnRH receptor agonist.
Medchemexpress LLC Ceftolozane trifluoroacetate salt | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 25 MG
Ceftolozane TFA is the trifluoroacetate salt of ceftolozane, a cephalosporin-class antibiotic active against Gram-negative bacteria. It is provided for research use in antibacterial studies, assay development, and medicinal chemistry where it can serve as a synthetic intermediate for the design and optimization of novel antibiotic candidates.
- Trifluoroacetate salt form for improved stability and handling.
- Active against Gram-negative bacteria.
- Suitable for medicinal chemistry and synthetic applications.
- Available in small research quantities for assay development.
- Characterized with confirmed purity and molecular weight.
Medchemexpress LLC GIP, rat TFA | 99.8% | 5002.58 | 5 MG
GIP, rat TFA is a bioactive peptide of rat origin, also known as glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide. This 42-amino acid peptide is released by K cells in the duodenum and jejunum in response to food intake. GIP, along with GLP, stimulates insulin secretion from pancreatic beta cells and appears to promote beta cell proliferation and survival. Recent studies suggest a role for GIP in lipid homeostasis and a potential function in the pathogenesis of obesity.
- Bioactive peptide of rat origin
- 42-amino acid peptide
- Released by K cells in duodenum and jejunum
- Stimulates insulin secretion from pancreatic beta cells
- Promotes beta cell proliferation and survival
- Plays a role in lipid homeostasis
Medchemexpress LLC GHRF, mouse TFA (mouse growth hormone-releasing factor TFA) | 98.9% | 5032.74 | 25 MG
GHRF, mouse TFA is a mouse growth hormone-releasing factor. It is a peptide composed of 44 amino acids. This substance stimulates the release and synthesis of growth hormone. It is intended for research use only and not for sale to patients.
- Appearance: white to off-white solid
- Stimulates release and synthesis of growth hormone
- Suitable for research use only
- Peptide sequence: His-Val-Asp-Ala-Ile-Phe-Thr-Thr-Asn-Tyr-Arg-Lys-Leu-Leu-Ser-Gln-Leu-Tyr-Ala-Arg-Lys-Val-Ile-Gln-Asp-Ile-Met-Asn-Lys-Gln-Gly-Glu-Arg-Ile-Gln-Glu-Gln-Arg-Ala-Arg-Leu-Ser
- Store sealed, away from moisture
- Powder storage: -80°C for 2 years; -20°C for 1 year
- In-solvent storage: -80°C for 6 months; -20°C for 1 month
- In vitro solubility in DMSO: 100 mg/mL (requires ultrasonic)
- Comprehensive documentation available
Medchemexpress LLC Crotamine (TFA) | 98.1% | 4883.73 | 5 MG
Crotamine TFA is a Na+ channel modulator. It is a 42 amino acid toxin cross-linked by three disulfide bridges. It has analgesic activity and also interacts with lipid membranes, showing myonecrotic activity. Crotamine can be isolated from *Crotalus durissus terrificus* venom.
- Na+ channel modulator
- 42 amino acid toxin
- Cross-linked by three disulfide bridges
- Analgesic activity
- Interacts with lipid membranes
- Shows myonecrotic activity
- Isolated from *Crotalus durissus terrificus* venom
Medchemexpress LLC Bibo3304 | 191868-14-1 | 100.0% | 643.66 | C31H36F3N7O5 | 25 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research probe. It exhibits subnanomolar affinity at human and rat Y1 receptors (IC50 = 0.38 nM and 0.72 nM) and is supplied in solid and solution formats with high reported purity.
- High potency with subnanomolar IC50 values for human and rat Y1 receptors.
- High reported purity (99.96%).
- Available as solid and as a 10 mM DMSO solution for assay readiness.
- Molecular formula C31H36F3N7O5 and molecular weight 643.66 g/mol.
- Suitable for receptor pharmacology and in vitro pharmacodynamic studies.
Medchemexpress LLC C(avb6)-DOTA (TFA) | 98.6% | 1546.65 | 5 MG
C(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with a DOTA chelator. The Lu(III) complex of this product has a comparable affinity for αvβ6 integrin (IC50=0.8 nM) and can be used as a tumor diagnostic.
- Conjugate of αvβ6 integrin selective peptide ring
- Modified with DOTA chelator
- Lu(III) complex shows high affinity for αvβ6 integrin (IC50=0.8 nM)
- Applicable in tumor diagnostics
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%