Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Pam2CSK4 (TFA) | 99.5% | 1271.82 (free base) | 5 MG
Pam2CSK4 (TFA) is a lipopeptide that acts as a TLR6-independent TLR2 ligand and agonist. It promotes platelet aggregation and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages.
- Acts as a TLR6-independent TLR2 ligand and agonist.
- Promotes platelet aggregation.
- Increases platelet adhesion to collagen-coated surfaces.
- Activates iNOS expression and NO production in mouse macrophages.
Medchemexpress LLC Wrwyar-NH2 TFA | 70.8% | 936.07 | 5 MG
Wrwyar-NH2 TFA is a control peptide primarily targeting DNA/RNA synthesis. It plays a role in the Cell Cycle/DNA Damage pathway. This product is intended for research use only and has not been fully validated for medical applications.
- Control peptide
- Targets DNA/RNA synthesis
- Involved in cell cycle/DNA damage pathway
- For research use only
Medchemexpress LLC NLS-StAx-h TFA | 98.9% | 3559.28 | 1 MG
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide that inhibits Wnt signaling, with an IC50 of 1.4 μM. It effectively inhibits interactions between β-catenin and transcription factors and demonstrates anti-proliferative effects on cancer cells, including SW-480 and DLD-1 colorectal cancer cells.
- Selective, cell permeable, stapled peptide
- Inhibits Wnt signaling with an IC50 of 1.4 μM
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation of cancer cells
- Inhibits proliferation of colorectal cancer cells (SW-480 and DLD-1 cells) by more than 80% at 10 μM
- Inhibits migration of DLD-1 colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC Goralatide TFA | 1796568-94-9 | 98.0% | 1 MG
Goralatide TFA is an inhibitor of cell cycle progression that enhances the selectivity of hyperthermic purging of human progenitor cells. It has potential for research related to leukemia.
- Inhibits cell cycle progression.
- Enhances selectivity of hyperthermic purging of human progenitor cells.
- Potential for leukemia research.
Medchemexpress LLC Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Medchemexpress LLC NNC9204-1177 (TFA) | 98.7% | 4570.07 (free base) | 1 MG
NN1177 TFA is a long-acting GLP-1/glucagon receptor co-agonist. It can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice and reduces CYP3A4 mRNA expression and activity in human hepatocytes. It can also reduce liver fat and inflammatory and fibrosis biomarkers in a NASH mouse model.
- Induces dose-dependent body weight loss in diet-induced obese (DIO) mice.
- Reduces CYP3A4 mRNA expression and activity in human hepatocytes.
- Reduces liver fat and inflammatory and fibrosis biomarkers in a NASH mouse model.
Medchemexpress LLC F11R peptide TFA | 97.6% | 1459.58 | 5 MG
F11R peptide TFA is an F11 receptor molecule that inhibits anti-F11R antibody-induced platelet aggregation and the adhesion of platelets to cytokine (TNFα and INF-γ)-inflamed endothelial cells. It can be used for research of atherosclerotic plaques and associated thrombotic disease.
- Inhibits anti-F11R antibody-induced platelet aggregation.
- Inhibits the adhesion of platelets to cytokine (TNFα and INF-γ)-inflamed endothelial cells.
Medchemexpress LLC Siivfekl (Tfa) | 99.9% | 948.16 | 5 MG
SIIVFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. It is an antigenic peptide used in experimental settings to stimulate specific T cells and study competitive interactions. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for CD8+ T cell detection.
- Antigenic peptide.
- Stimulates specific T cells.
- Exhibits low affinity for OT-I T cell receptor (TCR).
- Used for detection of CD8+ T cells.
- Soluble in H2O at ≥ 2 mg/mL.
Medchemexpress LLC AMARA peptide TFA | 98.53% | 1640.84 | 5 MG
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK). This peptide is commonly used in biochemical research to study the activity and regulation of these kinases.
- Substrate for SIK and AMPK
- Used in biochemical research
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | 98.04% | 25 MG
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor, demonstrating anti-cancer activity. It effectively inhibits JAK2, FLT3, JAK1, and JAK3, and has shown significant effects in both laboratory and animal studies.
- Potent dual JAK2/FLT3 inhibitor
- Exhibits anti-cancer activity
- Down-regulates p-FLT3 in a dose-dependent manner
- Induces apoptosis and G1/G0 cell cycle arrest in MV4-11 cells
- Shows significant antitumor effects in NOD/SCID mouse models
Medchemexpress LLC Ala-MPSD TFA | 98.02% | 3016.76 | 5 MG
Ala-MPSD TFA is a control peptide for MPSD (HY-P10471). In Ala-MPSD TFA, the four serine residues of MPSD are substituted by alanines.
- Control peptide for MPSD (HY-P10471)
- Four serine residues of MPSD are substituted by alanines
- Molecular formula: C147H243N41O27.XC2HF3O2
- Sequence: Lys-Lys-Lys-Lys-Lys-Arg-Phe-Ala-Phe-Lys-Lys-Ala-Phe-Lys-Leu-Ala-Gly-Phe-Ala-Phe-Lys-Lys-Asn-Lys-Lys
- Purity: 98.02% (HPLC)
- Appearance: White to off-white (solid)
- MS consistent with structure
Medchemexpress LLC Peptide5 TFA | 98.9% | 1509.60 | 1 MG
A connexin 43 mimetic peptide, it reduces animal swelling, astrogliosis, and neuronal cell death after spinal cord injury. It also inhibits NLRP3 inflammasome, and is an anti-inflammatory agent.
- Reduces animal swelling after spinal cord injury.
- Reduces astrogliosis after spinal cord injury.
- Reduces neuronal cell death after spinal cord injury.
- Inhibits NLRP3 inflammasome.
- Acts as an anti-inflammatory agent.
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 100 UG
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker. It has IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels. It inhibits glutamate exocytosis and calcium influx elicited by high potassium (IC50, 30-225 nM), and blocks the high potassium-induced release of serotonin and norepinephrine. It has no effect on L-type or N-type calcium channels.
- Potent and selective P/Q type Ca2+ (Cav2.1) channel blocker
- Inhibits glutamate exocytosis and calcium influx
- Blocks high potassium-induced release of serotonin and norepinephrine
- Does not affect L-type or N-type calcium channels
Medchemexpress LLC mP6 (TFA) | 2700321-79-3 | 990.15 | 1 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide that functions as an Integrin β(3) Inhibitor. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. Additionally, mP6 blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Functions as an Integrin β(3) Inhibitor
- Inhibits the interaction of Gα13 with integrin β3
- Does not disrupt talin-dependent integrin function
- Blocks the GTP usage of Rac1, Rap1, and Rab7
- Effectively inhibits the infection of CHO-A24 cells
Medchemexpress LLC Biotin-COG1410 TFA | 98.0% | 1 MG
Biotin-COG1410 TFA is a biotin-labeled COG1410. COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. It exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI) and can be used for the research of neurological diseases.
- Decreases the production and release of NO and TNFα in BV2 microglia cells.
- Exhibits significant improvement on vestibulomotor function and spatial learning and memory in mice.
- Improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats.